COVID-19 NEUROLOGY

The COVID-19 pandemic, caused by SARS-CoV-2, is of a scale not seen since the 1918 influenza pandemic. Although the predominant clinical presentation is with respiratory disease, neurological manifestations are being recognised increasingly. This webinar reviewed what’s known about neurological manifestations of SARS CoV-2 and related coronaviruses, consider the disease mechanisms and outline a framework for future investigative studies. This series is brought together by the COVID Neuro Network and the Liverpool Brain Infections Group. Find out more by visiting: https://braininfectionsglobal.tghn.org 1 May 2020

Professor of Neurology, Joseph R. Berger, M.D. discusses the Neurological Implications of COVID-19. 0:00 Intro 0:35 Neurological Complications of COVID-19 1:15 Emerging Infectious Disease 2:25 Hotspots 3:04 Background on COVID-19 5:15 Worldwide distribution of COVID-19: April 24, 2020 5:35 Distribution of COVID-19 in U.S.: May 8, 2020 6:08 About Coronavirus 10:05 Coronavirus - Evolution of Human Virus 11:43 Ace 2 Receptor Expression 14:35 Clinical Manifestations of COVID-19 17:35 Pulmonary Imaging Studies with COVID-19 18:18 Skin Manifestations of COVID-19 19:20 Pediatric Multi-System Inflammatory Syndrome 20:10 Thought from Lewis Thomas 21:20 Neuroinvasion of Coronavirus: Potential Pathways 23:02 Neurological Disease with Coronaviruses 26:34 Meningitis/Encephalitis with SARS: Patient Case 27:10 Spectrum of Neurological Complications of COVID-19 30:17 Nature and Frequency of Neurological Manifestations from Wuhan 31:55 Anosmia and Ageusia with COVID-19 32:49 Meningitis/Encephalitis with COVID-19: Patient Cases 36:26 Acute Hemorrhagic Necrotizing Encephalitis with COVID-19 37:33 About Acute Necrotizing Encephalopathy 38:32 Hypoxic-ischemic Encephalopathy with COVID-19: Patient Case 39:18 Stroke with COVID-19 41:27 Acute Myelitis with COVID-19: Patient Case 42:27 ADEM with COVID-19: Patient Case 43:27 GBS and Miller Fisher Syndrome with COVID-19 44:05 Neuroinflammatory Disorders and COVID-19 46:45 Penn Experience with COVID-19 in MS 49:18 Long Term Neurological Sequelae of COVID-19 50:10 Final Thoughts and Opinions 52:05 Q&A #PennMedicine

In this UCSF Medical Grand Rounds presentation (April 30, 2020), UCSF experts provide an update on the clinical & neurological manifestations for COVID-19, and on contact tracing. We also hear a report from UCSF physicians who are working with hospitals in New York City. The session is hosted by UCSF Department of Medicine chair Bob Wachter. Program Bob Wachter: Introduction 00:02:36 – Brian Schwartz, Professor, Dept. of Medicine, Division of Infectious Diseases – Update on Clinical Manifestations of Covid-19 00:23:14 – Andy Josephson, Professor and Chair, Dept. of Neurology – Neurological Manifestations of Covid-19 00:34:51 – Q&A 00:43:09 – Michael Reid, Assistant Professor, Dept. of Medicine, Division of HIV, Infectious Diseases & Global Medicine, ZSFG – Scientific and Practical Aspects of Contact Tracing 01:01:32 – Q&A 01:04:43 – Panel Discussion on Covid-19 in New York City • Amir Jaffer, Chief Medical Officer, New York-Presbyterian Queens – managing the Covid-19 surge at New York-Presbyterian Queens • Sanjay Reddy, Associate Professor, UCSF Dept. of Medicine, Division of Hospital Medicine – experience working at New York-Presbyterian Queens • Alex Smith, Associate Professor, UCSF Dept. of Medicine, Division of Geriatrics – experience from performing teleconsults in New York • Carly Zapata, Assistant Professor, UCSF Dept. of Medicine, Division of Palliative Medicine – experience from performing teleconsults in New York 01:42:00 – Bob Wachter: Closing See previous Covid-19 Medical Grand Rounds: • April 23: Update on Covid-19: The Next Stage of the Pandemic, Virology & Diagnostics https://www.youtube.com/watch?v=zJKrnpG_dAE&feature=youtu.be • April 16: Update on Covid-19: Epidemiology, Treatments, and Health Disparities https://www.youtube.com/watch?v=o1I2KlWPw9I& • April 9: Update on Covid-19, at UCSF and Around the Country https://www.youtube.com/watch?v=Odngvcd45ZY • April 2: Epidemiology, Science, Clinical Aspects, and Therapy for Covid-19, Part 2 https://www.youtube.com/watch?v=UdUci2Y9QB8&feature=youtu.be • March 26: Impact on Covid-19 on Medical Education https://www.youtube.com/watch?v=HzRAoS7Ubl4 • March 26: UCSF Researchers Tackling Covid-19 https://www.youtube.com/watch?v=jBAS8lc3z9M • March 19: Epidemiology, Science, Clinical Aspects, and Therapy for Covid-19, Part 1 https://www.youtube.com/watch?v=bt-BzEve46Y&t=171s

In this episode, Richard S. Isaacson, MD, FAAN, talks with Sanjay Gupta, MD, CNN Chief Medical Correspondent and Associate Chief of Neurosurgery, Grady Memorial Hospital on the global perspective in the fight against COVID-19. We cover how this pandemic compares to other catastrophes, how the neurology workforce will be called upon to help, strategies on keeping up with emerging data, and thoughts on when the most serious phase may come to an end. Stay up-to-date with the latest information and resources on the AAN’s COVID-19 Neurology Resource Center: http://www.aan.com/COVID19 This content is made available for voluntary, informational purposes and does not constitute medical or legal advice. The views and opinions expressed do not necessarily reflect those of the American Academy of Neurology. Connect with the AAN Twitter: https://bit.ly/1orvPet Instagram: http://bit.ly/2eVgsz4 Facebook: http://bit.ly/2feMxW4 LinkedIn: http://bit.ly/22mKzkM

Sherry H-Y Chou, MD, M.Sc, FNCS, FCCM, joins Richard S. Isaacson, MD, FAAN, for a conversation about potential neurological complications with COVID-19. In this episode, we discuss two new international studies, as well as the balance between gathering data and caring for coronavirus patients. Learn more about the study Dr. Chou is conducting: https://www.neurocriticalcare.org/resources/covid19 Stay up-to-date with the latest information and resources on the AAN’s COVID-19 Neurology Resource Center: http://www.aan.com/COVID19 This content is made available for voluntary, informational purposes and does not constitute medical or legal advice. The views and opinions expressed do not necessarily reflect those of the American Academy of Neurology. Connect with the AAN Twitter: https://bit.ly/1orvPet Instagram: http://bit.ly/2eVgsz4 Facebook: http://bit.ly/2feMxW4 LinkedIn: http://bit.ly/22mKzkM

In December 2019, China reported an outbreak of a novel human coronavirus, SARS-CoV-2 in the Hubei Province of Wuhan. Over the past 4 months, the local outbreak has become a global pandemic, infecting more than half a million patients, and leading to thousands of deaths. The neurologic manifestations of SARS-CoV-2 infection are incompletely described, but many patients may demonstrate early anosmia, and a small proportion of patients suffer from acute cerebrovascular disease. To view more NeuroBytes visit http://www.AAN.com/view/NeuroBytes Music: "Inspired" by Kevin MacLeod, Incomptech (https://incompetech.filmmusic.io/) Visit the American Academy of Neurology at https://www.aan.com Connect with the AAN Facebook: http://bit.ly/2feMxW4 Twitter: https://bit.ly/1orvPet Instagram: http://bit.ly/2eVgsz4 LinkedIn: http://bit.ly/22mKzkM

Originally identified as a respiratory disease, some COVID-19 patients exhibit neurologic symptoms including stroke, loss of consciousness, headache, and even the loss of taste and smell. What's unknown is whether these are direct effects of the virus entering the nervous system, or consequences of the disease's effect on the body. On the Mayo Clinic Q&A podcast, Dr. Allen Aksamit Jr., a Mayo Clinic neurologist, discusses potential neurological effects of COVID-19. This interview was recorded on April 23, 2020. Learn more about COVID-19: https://www.mayoclinic.org/coronavirus-covid-19?mc_id=us&utm_source=youtube&utm_medium=sm&utm_content=video&utm_campaign=mayoclinic&geo=national&placementsite=enterprise&cauid=100504